发明名称 |
Antagonist Against Tolerance to Anticancer Drugs |
摘要 |
An ABC transporter protein expression inhibitor comprising, as the active ingredient(s), 0.001 to 100 nM of one or more members selected from among steroid hormones, compounds having a female hormone function, analogous compounds thereof and antagonistic inhibitors therefor; an anticancer composition containing this ABC transporter protein expression inhibitor and an anticancer drug; and cells useful in the development of an anticancer drug. The present invention provides a drug which inhibits the expression of an ABC transporter to thereby overcome resistance to anticancer drugs; cancer cells useful in screening such drugs; and an anticancer drug efficacious even against such a cancer as having acquired resistance to anticancer drugs.
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申请公布号 |
US2008249036(A1) |
申请公布日期 |
2008.10.09 |
申请号 |
US20050661353 |
申请日期 |
2005.08.31 |
申请人 |
YOSHIKAZU SUGIMOTO;JAPANESE FOUNDATION FOR CANCER RESEARCH;KABUSHIKI KAISHA YAKULT HONSHA |
发明人 |
SUGIMOTO YOSHIKAZU;TSUKAHARA SATOMI;IMAI YASUO |
分类号 |
A61K31/704;A61K31/56;A61P35/00;C07J1/00;C12N5/00;C12Q1/02 |
主分类号 |
A61K31/704 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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