Inhibitors of Protein Kinase a Anchoring

摘要

A PKA I anchoring disrupting molecule or AKAP mimic, wherein said molecule or mimic is a polypeptide which comprises the following amino acid sequence: X₁ X₂ X₃ Y A X₄ X₅ L A X₆ X₇ X₈ I X₉ X₁₀ X₁₁ X₁₂ X₁₃ (sequence (1)) or a peptidomimetic or analogue thereof is provided. Also provided are antibodies to the molecule, nucleic acid molecules comprising a sequence encoding the molecule and pharmaceutical compositions. A method of altering the PKA type I signalling pathway in a cell by administration of the anchoring disruption molecule or AKAP mimic, in particular to treat immunosuppressive disorders, proliferative diseases or autoimmune diseases is also provided.