发明名称 |
INTERMEDIATES AND A PROCESS EMPLOYING THE INTERMEDIATES FOR THE PREPARATION OF (3-TRIFLUOROMETHYLSULFONYL)-N-[4-METHYL-3-(4-PYRIDIN-3YL-PYRIMIDIN-2YLAMINO)-PHENYL]-BENZAMIDE |
摘要 |
This invention relates to a process for the preparation of (3-trifluoromethylsulfonyl)-N-[4-methyl-3-(4-pyridin-3yl-pyrimidin-2ylamino)-phenyl]-benzamide (formula (I)) starting from 4-methyl-2-nitro-aniline (formula (II)) through intermediates (3-trifluoromethylsulfonyl)-N-[4-methyl-3-nitrophenyl]-benzamide (formula (III)), (3-trifluoromethylsulfonyl)-N-[3-amino-4-methylphenyl]-benzamide (formula (IV)) and (3-trifluoromethylsulfonyl)-N-[3-guanidino-4-methylphenyl]-benzamide (formula (V)). This invention also relates to processes for the preparation of these intermediates. The compound of formula (I), also known as AN-024, is:
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申请公布号 |
US2008249121(A1) |
申请公布日期 |
2008.10.09 |
申请号 |
US20080042240 |
申请日期 |
2008.03.04 |
申请人 |
NATCO PHARMA LIMITED |
发明人 |
KOMPELLA AMALA KISHAN;ADIBHATLA KALI SATYA BHUJANGA RAO;RACHAKONDA SREENIVAS;VENKAIAH CHOWDARY NANNAPANENI |
分类号 |
A61K31/506;A61P35/00;C07C233/66;C07C279/18;C07D401/04 |
主分类号 |
A61K31/506 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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