| 发明名称 |
HIGH-PRESSURE INCLUSION BODY SOLUBILIZATION AND PROTEASE CLIPPING OF RECOMBINANT FUSION PROTEINS |
| 摘要 |
Described herein are methods for the solubilization and proteolytic cleavage of fusion protein aggregates, including autocatalytic fusion proteins, at pressures greater than atmospheric pressure to yield soluble target polypeptides.
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| 申请公布号 |
US2008248522(A1) |
申请公布日期 |
2008.10.09 |
| 申请号 |
US20080098877 |
申请日期 |
2008.04.07 |
| 申请人 |
SEEFELDT MATTHEW B;HESTERBERG LYNDAL K;RANDOLPH THEODORE W;CARPENTER JOHN F |
发明人 |
SEEFELDT MATTHEW B.;HESTERBERG LYNDAL K.;RANDOLPH THEODORE W.;CARPENTER JOHN F. |
| 分类号 |
C12P21/06;C07K2/00 |
主分类号 |
C12P21/06 |
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