| 摘要 |
The invention relates to the field of biochemistry, biophysical chemistry, molecular biology, structural biology and medicine. More in particular, the invention relates to cross-beta structure conformation. The invention provides a method for determining a difference in the cross-beta structure content of a protein in a reference sample compared to said protein in a test sample wherein the test sample has been subjected to a treatment that is expected to have an effect on the cross-beta structure content of said protein comprising-determining in said reference sample the cross-beta structure content of said protein-subjecting said protein to a treatment that is expected to have an effect on the cross-beta structure content to obtain said test sample-determining in said obtained test sample the cross-beta structure content of said protein-determining whether the cross-beta structure content of the reference sample is different from the cross-beta structure content in the test sample.
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