SYSTEMS AND METHODS FOR DELIVERING A RAPAMYCIN ANALOG THAT DO NOT INHIBIT HUMAN CORONARY ARTERY ENDOTHELIAL CELL MIGRATION
摘要
A drug-eluting endoprosthesis is configured for inhibiting restenosis and thrombosis, and for promoting healing of a lesion in a body of a subject. Such an endoprosthesis includes at least a supporting structure and a therapeutically effective amount of the rapamycin analog is disposed thereon. The therapeutically effective amount of the rapamycin analog allows for the rapamycin analog to elute from the supporting structure so as to obtain a concentration of the rapamycin analog that is sufficient for inhibiting restenosis and/or inhibiting thrombosis. Also, the therapeutically effective amount of rapamycin analog is substantially devoid of inhibiting cell migration such that migrating cells promote healing of the lesion.
申请公布号
WO2007137296(A3)
申请公布日期
2008.10.09
申请号
WO2007US69579
申请日期
2007.05.23
申请人
ABBOTT LABORATORIES;MACK, MATTHEW;BURKE, SANDRA;TONER, JOHN;CROMACK, KEITH
发明人
MACK, MATTHEW;BURKE, SANDRA;TONER, JOHN;CROMACK, KEITH