发明名称 |
CHEMOTHERAPEUTIC CONJUGATES AND METHODS OF USE |
摘要 |
Chemotherapeutic conjugates of a peptide substrate to a phosphoramide chemotherapeutic agent in which a peptide substrate is covalently linked to the chemotherapeutic agent by a linker with an aminoarylmethyl or aminoheteroaryl moiety, wherein the linking of the peptide to the chemotherapeutic agent inhibits the cytotoxic activity of the chemotherapeutic agent, the peptide is a substrate for proteolytic cleavage by a tumor-specific enzyme; and the linker is capable of undergoing 1, 6-elimination in vivo upon cleavage of the peptide substrate. Methods for synthesizing and methods of using the conjugates are also disclosed.
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申请公布号 |
WO2008067495(A3) |
申请公布日期 |
2008.10.09 |
申请号 |
WO2007US85981 |
申请日期 |
2007.11.29 |
申请人 |
RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY;HU, LONGQIN;WU, XINGHUA |
发明人 |
HU, LONGQIN;WU, XINGHUA |
分类号 |
A01N57/00;A61K38/00;C07K16/00 |
主分类号 |
A01N57/00 |
代理机构 |
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代理人 |
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地址 |
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