| 摘要 |
PROBLEM TO BE SOLVED: To provide a sensitization nature evaluation method of easily and objectively evaluating the strength of a respirator sensitization nature at the time when chemical substances and natural substances directly reach a trachea or a lung. SOLUTION: The sensitization nature evaluation method is to relatively evaluate the strength of the respirator sensitization nature by quantifying the respirator sensitization symptoms, and after a known respirator sensitization substance and a test substance are directly administrated in a trachea of a small animal with different concentrations, the respirator sensitization symptoms induced in the trachea or the lung of the small animal are quantitively measured with at least a method chosen from the scoring of histological findings, measurement of allergic inflammation cell number, quantification of cytokine, and quantification of antibodies, and then the obtained measurement results are relatively compared between the test substance and the standard substance to determine the respirator sensitization nature of the test substance. COPYRIGHT: (C)2009,JPO&INPIT
|
