PROCESS FOR PREPARING A SUBSTRATE COATED WITH A BIOMOLECULE
摘要
Processes are provided for preparing a substrate coated with a biomolecule, comprising: a) providing a substrate; b) coating the substrate with a polysiloxane, typically by exposing the substrate to a reactive gas containing siloxane functional groups and to plasma energy to yield a plasma-deposited polysiloxane surface on the substrate; c) rendering the polysiloxane surface amino functional; and d) contacting the amino-functional polysiloxane surface with a biomolecule under conditions effective to attach the biomolecule to the substrate. The coated substrate may be a medical device that demonstrates an ability to maintain gas permeability when in contact with blood or blood components, compared to a substantially identical medical device that has not been coated with a biomolecule using this process.
申请公布号
WO2008122034(A1)
申请公布日期
2008.10.09
申请号
WO2008US59115
申请日期
2008.04.02
申请人
ENSION, INC.;CAHALAN, PATRICK;CAHALAN, LINDA;JOHNSON, GREG;GARTNER, MARK
发明人
CAHALAN, PATRICK;CAHALAN, LINDA;JOHNSON, GREG;GARTNER, MARK