发明名称 |
Cross-species-specific bispecific binders |
摘要 |
The present invention relates to a polypeptide comprising a first human binding domain capable of binding to an epitope of human and non-chimpanzee primate CD3 (epsilon) chain and a second binding domain capable of binding to EGFR, Her2/neu or IgE of a human and/or a non-chimpanzee primate as well as to a process for the production of the mentioned polypeptide. The invention further relates to nucleic acids encoding for the polypeptide, to vectors comprising the same and to host cells comprising the vector. In another aspect, the invention provides for a pharmaceutical composition comprising the mentioned polypeptide and medical uses of the polypeptide. |
申请公布号 |
AU2008234019(A1) |
申请公布日期 |
2008.10.09 |
申请号 |
AU20080234019 |
申请日期 |
2008.04.03 |
申请人 |
MICROMET AG |
发明人 |
ELKE BURGHART;CLAUDIA BLUMEL;PETRA MEIER;DORIS RAU;SUSANNE MANGOLD;SUSANNE STRASSER;PETRA MAYER;CAROLA STEIGER;RALF LUTTERBUSE;MATTHIAS KLINGER;EVELYN EBERT;PETER KUFER;TOBIAS RAUM;ROMAN KISCHEL;SANDRA WISSING;PATRICK HOFFMANN;EVELYNE SCHALLER;MAJK KVESIC;MIRNAALINI SRISKANDARAJAH;RONNY CIERPKA;SUSANNE HAUSMANN;GERT RIETHMULLER |
分类号 |
C07K14/725;C07K16/28;C07K16/30;C07K16/32;C07K16/42;C07K16/46 |
主分类号 |
C07K14/725 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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