发明名称 |
MANNOSE DERIVATIVES FOR KILLING TUMOR CELLS |
摘要 |
A method for treating cancer by killing selected tumor cells such as human breast, non-small cell lung cancer cells, pancreatic cancer cells, osteosarcoma cancer cells, and glioblastoma cells, includes administering to a patient in need of treatment, an effective amount of at least one mannose analog such as 2-DG or 2-FM or 2-CM. The killing is believed to be due to an interference with glycosylation. A theranostic method includes determining whether a patient. cancer tumor sample comprises cells sensitive to killing to at least one mannose analog due to an interference with glycosylation. |
申请公布号 |
WO2007100728(A3) |
申请公布日期 |
2008.10.09 |
申请号 |
WO2007US04845 |
申请日期 |
2007.02.26 |
申请人 |
UNIVERSITY OF MIAMI;LAMPIDIS, THEODORE, J.;KURTOGLU, METIN;MATHER, JOHN |
发明人 |
LAMPIDIS, THEODORE, J.;KURTOGLU, METIN;MATHER, JOHN |
分类号 |
A01N43/04;A61K31/70 |
主分类号 |
A01N43/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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