METHOD OF FORMING A TABLET COMPRISING PRE-BLEND OF IBUPROPEN AND SILICON DIOXIDE
摘要
A method of forming a tablet includes the steps of pre-blending an active pharmaceutical ingredient susceptible to tackiness and a blending additive with a first mixing effort to form a pre-blend mixture, wherein the first mixing effort and a second mixing effort, resulting from mixing at least one excipient with the pre-blend mixture, form a blend suitable for direct compression and compressing the blend to form the tablet. One way of achieving the first mixing effort is to pre-blend for an extended period of time. The method allows for directly compressing the blend without the need for a granulation step or roller compression. One such active pharmaceutical ingredient susceptible to tackiness is ibuprofen.
申请公布号
WO2008069938(A3)
申请公布日期
2008.10.09
申请号
WO2007US24489
申请日期
2007.11.28
申请人
SCOLR PHARMA, INC.;HITE, MICHAEL;FEDERICI, CATHY;BRUNELLE, ALAN;TURNER, STEPHEN
发明人
HITE, MICHAEL;FEDERICI, CATHY;BRUNELLE, ALAN;TURNER, STEPHEN