| 摘要 |
A polymeric micelle type drug comprises at least one hydrophobic drug physically trapped in a drug carrier comprising a block copolymer represented by formula I or II: <CHEM> <CHEM> wherein R1 is hydrogen or an alkyl group having 1 to 20 carbo atoms, R2 is NH, CO, R6(CH2)qR7 (in which R6 represents OCO, OCONH, NHCO, NHCOO, NHCONH, CONH or COO, R7 represents NH or CO, and q is 1 to 6), R3 is hydrogen, an alkyl group having 1 to 20 carbon atoms, (CH2)pC6H5, (CH2)pCOOR5 or CH2CONHR5 (in which p is 1 or 2, R5 represents a C1-20 alkyl group, a benzyl-substituted C1-20 alkyl group or a benzyl group), R4 is hydrogen, hydroxyl, RCO-, RNH- or RO- where R is an alkyl group having 1 to 20 carbon atoms, m is 4-2500, and n is 2-300. |
