发明名称 |
METHODS FOR IDENTIFYING COMPOUNDS THAT MODULATE UNTRANSLATED REGION-DEPENDENT GENE EXPRESSION AND METHODS OF USING SAME |
摘要 |
The present invention relates to methods for identifying compounds that modulate untranslated region-dependent expression of a target gene. The invention particularly relates to using untranslated regions of a target gene or fragments thereof linked to a reporter gene to identify compounds that modulate untranslated region-dependent expression of a target gene. The methods of the present invention provide a simple, sensitive assay for high-throughput screening of libraries of compounds to identify pharmaceutical leads. |
申请公布号 |
WO2004065561(A3) |
申请公布日期 |
2008.10.09 |
申请号 |
WO2004US01643 |
申请日期 |
2004.01.21 |
申请人 |
PTC THERAPEUTICS, INC.;CAO, LIANGXIAN;TRIFILLIS, PANAYIOTA |
发明人 |
CAO, LIANGXIAN;TRIFILLIS, PANAYIOTA |
分类号 |
C12Q1/68;C07K14/52;C12N15/10 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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