PROANTHOCYANIDINS FROM CINNAMON AND ITS WATER SOLUBLE EXTRACT INHIBIT TAU AGGREGATION
摘要
Compositions comprising proanthocyanidin compositions (e.g. those extracted from cinnamomum species) that are observed to bind tau and inhibit its aggregation as well as methods for making and using such compositions are disclosed. In certain embodiments of the invention, the proanthocyanidins can be used as a probe to identify and/or characterize tau isoforms in a variety of contexts. In other embodiments of the invention, these compositions are used in methods designed to treat neurological disorders associated with tau aggregation (e.g. Alzheimer's disease).
申请公布号
WO2008121412(A1)
申请公布日期
2008.10.09
申请号
WO2008US04236
申请日期
2008.03.31
申请人
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA;LEW, JOHN;GRAVES, DONALD, J.