METHODS AND COMPOSITIONS FOR THE TREATMENT OF PROLIFERATIVE DISEASES

摘要

The invention features peptides containing domain 4 of the Streptococcus intermedius intermedilysin (ILY) protein and fragments thereof, and the use of these peptides to sensitize cancer cells to antibody based anticancer tre atments. CD59 receptor activity has been associated with a decreased sensiti vity to therapeutic antibodies. Desriably, administration of ILY domain 4 po lypeptides is sufficient to inhibit CD59 receptor activity while avoiding th e general toxicity associated with full length ILY.