| 摘要 |
The present invention relates to a method of forming granules of (2R,3S,4 R,5R)-5-(4-amino-2-oxo-2 H -pyrimidin-1-yl)-2-azido-3,4-bis -iso-butyryloxy- tetrahydro-furan-2-ylmethyl isobutyrate; hydrochloride salt (I), comprising mixing I, with a granulating amount of a granulating liquid, and a polyethyl ene glycol (PEG)/polypropylene glycol (PPG) block copolymer as a binder and solubility enhancer to form wet granules which are then dried to remove the granulating liquid.
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