COMPOSITION OF LABELED AND NON-LABELED MONOCLONAL ANTIBODIES

摘要

This invention relates to a composition of labeled and non-labeled monocl onal antibodies directed to a human transmembrane protein for the simultaneo us treatment and diagnosis of diseases which are associated with an overexpr ession of such a protein especially of cancer. The invention further relates to a method of first administering said composition, determine the change o f labeled antibody concentration and afterwards administering the non-labele d monoclonal antibodies only such that the minimum required concentration of such non-labeled antibody for a favorable therapeutical effect is achieved and maintained in the treatment, while unfavorable side effects are minimize d due to the lower systemic antibody concentration.