PROTEINA INSECTICIDA HIBRIDA QUE COMPRENDE DOS PROTEINAS CRY DEL BACILLUS THURINGIENSIS (BT) DIFERENTES; MOLECULA DE ACIDO NUCLEICO QUE COMPRENDE DICHA PROTEINA; CASETE DE EXPRESION, VECTOR RECOMBINANTE QUE COMPRENDEN EL ACIDO NUCLEICO; CELULA TRANSG

摘要

Compositions and methods for controlling plant pests are disclosed. In particular, novel engineered hybrid insecticidal proteins (eHIPs) having toxicity to at least corn rootworm are provided. By fusing unique combinations of complete or partial variable regions and conserved blocks of at least two different Bacillus thuringiensis (Bt) Cry proteins or a modified Cry proteins an eHIP having activity against corn rootworm is designed. Nucleic acid molecules encoding the novel eHIPs are also provided. Methods of making the eHIPs and methods of using the eHIPs and nucleic acids encoding the eHIPs of the invention, for example in transgenic plants to confer protection from insect damage are also disclosed.