ANTICANCER COMPOUNDS WITH A BENZO ( 1, 2, 4 ) TRIAZIN-3YL-AMINE CORE

摘要

The invention provides compounds of the formulae (1), (2) and (3): (1, 2, 3), or salts, solvates or tautomers thereof; wherein G, A,v, m, X^a, X^b, X^c, X^d, X^e, R², R³, R⁴, Ar¹, Ar², R⁶, R¹⁰, R¹¹, R¹² and R¹³ are as defined in the claims. The compounds have activity against various kinases or, in the case of N-oxides, are reduced in hypoxic tissues to give compounds having kinase inhibiting activity.