HETEROCYCLIC COMPOUNDS AND THEIR USES

摘要

Substituted bicyclic heteroaryls and compositions containing them, for th e treatment of general inflammation, arthritis, rheumatic diseases, osteoart hritis, inflammatory bowel disorders, inflammatory eye disorders, inflammato ry or unstable bladder disorders, psoriasis, skin complaints with inflammato ry components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myesteni a gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopa thic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hype rsensitivity, The present invention also enables methods for treating cancer s that are mediated, dependent on or associated with p110 activity, includin g but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Mye lo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myel oid Leukemia (CML) T-cell Acute Lymphoblastic leukaemia ( T-ALL) B-cell Acut e Lymphoblastic leukaemia (B-ALL) Non Hodgkins Lymphoma (NHL) B-cell lymphom a and solid tumors, such as breast cancer.