发明名称 Sequencing single molecules using surface-enhanced Raman scattering
摘要 A surface-enhanced Raman scattering method and apparatus to sequence polymeric biomolecules such as DNA, RNA, or proteins is introduced. The method uses metallic nanostructures such as, for example, spherical or cylindrical Au or Ag nanoparticles having characteristic lengths of 10-100 nm which when illuminated with light of the appropriate wavelength produce resonant oscillations of the conduction electrons (plasmon resonance). Electric field enhancements of 30-1000 near the particle surface resulting from such oscillations increase Raman scattering cross-sections by about 10<SUP>6</SUP>-10<SUP>15 </SUP>due to the E<SUP>4 </SUP>dependence of the Raman scattering, wherein the largest enhancements occur in the gap/junction between novel closely spaced structures as disclosed herein.
申请公布号 US2008239307(A1) 申请公布日期 2008.10.02
申请号 US20070731418 申请日期 2007.03.30
申请人 THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 发明人 TALLEY CHAD E.;HUSER THOMAS R.;HOLLARS CHRISTOPHER W.;LANE STEPHEN M.
分类号 G01J3/44 主分类号 G01J3/44
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