发明名称 |
RECOMBINANT AAV PRODUCTION IN MAMMALIAN CELLS |
摘要 |
The present invention includes methods and compositions for the production of high titer recombinant Adeno-Associated Virus (rAAV) in a variety of mammalian cells. The disclosed rAAV are useful in gene therapy applications. Disclosed methods based on co- infection of cells with two or more replication-defective recombinant herpes virus (rHSV) vectors are suitable for high-titer, large-scale production of infectious rAAV. |
申请公布号 |
WO2008021140(A3) |
申请公布日期 |
2008.10.02 |
申请号 |
WO2007US17645 |
申请日期 |
2007.08.08 |
申请人 |
APPLIED GENETIC TECHNOLOGIES CORPORATION;HWANG, KYU-KYE;KNOP, DAVID |
发明人 |
HWANG, KYU-KYE;KNOP, DAVID |
分类号 |
C12N15/00;A61K48/00;C07H21/04;C07K14/015;C12N5/02;C12N7/01;C12N7/02 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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