发明名称 |
System and Method for Forming Bone, Ligament, and Bone-Ligament Constructs |
摘要 |
A system and method for forming a bone construct include providing bone marrow stromal cells on a substrate without disposing the cells within an exogenous scaffold, and culturing the cells in vitro in osteogenic media such that the cells form a confluent monolayer and detach from the substrate to form a self-organized three-dimensional bone construct. A system and method for forming a ligament construct using fibrogenic media and a system and method for forming a functionally integrated bone-ligament construct are also provided.
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申请公布号 |
US2008241209(A1) |
申请公布日期 |
2008.10.02 |
申请号 |
US20080025151 |
申请日期 |
2008.02.04 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
发明人 |
ARRUDA ELLEN M.;LARKIN LISA M.;SYED-PICARD FATIMA N.;SMIETANA MICHAEL;MA JINJIN |
分类号 |
A61F2/28;C12N5/077 |
主分类号 |
A61F2/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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