Triazolyl Derivatives of Azabicyclo [3.1.0] Hexane as Dopamine D3 Receptor Modulators

摘要

The present invention relates to novel compounds of formula (IC) or a salt thereof: wherein: p is an integer ranging from 0 to 4; R₁ is independently selected from a group consisting of: halogen, hydroxy, cyano, C_1-4alkyl, haloC_1-4alkyl, C_1-4alkoxy, haloC_1-4alkoxy, C_1-4alkanoyl or SF₅; or corresponds to a group R₅; m₁, m₂, m₃, and m₄ are 0; m₅, m₆ and m₇ are each independently 0, 1 or 2 wherein the sum of m₅, m₆ and m₇ is 1 or 2; R₆ is C_1-6alkyl; R₇ is halogen, C_1-6alkyl or haloC_1-6alkyl; R₂ is hydrogen or C_1-4alkyl; n is 2 or 3; X is S or -CH₂-; R₃ is C_1-4alkyl; R₄ is hydrogen, or a phenyl group, a heterocyclyl group, a 5- or 6-membered heteroaromatic group, or a 8- to 11-membered bicyclic group, any of which groups is optionally substituted by 1, 2, 3 or 4 substituents selected from the group consisting of: halogen, cyano, C_1-4alkyl, haloC_1-4alkyl, C_1-4alkoxy and C_1-4alkanoyl; R₅ is isoxazolyl, -CH₂-N-pyrrolyl, 1,1-dioxido-2-isothiazolidinyl, thienyl, thiazolyl, pyridyl or 2-pyrrolidinonyl, wherein each group is optionally substituted by one or two substituents selected from: halogen, cyano, C_1-4alkyl, haloC_1-4alkyl, C_1-4alkoxy and C_1-4alkanoyl; with the proviso that when m₅=m₆ =1 , R₇ is not chlorine; processes for their preparation, intermediates used in these processes, pharmaceutical compositions containing them and their use in therapy, as modulators of dopamine D₃ receptors, e.g. to treat substance related disorders, as antipsychotic agents, premature ejaculation or cognition impairment.