INDOLE DERIVATIVES AND THEIR METAL CONJUGATES AND USES THEREOF

摘要

Provided are compounds which are Indole derivatives, as well as pharmaceutical compositions containing the compounds. Also provided are methods of using the Indole compounds for preventing or treating a disease, or a condition that predisposes to a disease, wherein the disease or condition is associated with activation of the serine/threonine kinase B (Akt) in an animal. The method comprises administering to the animal a preventive or treatment effective amount of the Indole compound. Further provided is a method for increasing apoptosis of an animal cell comprising contacting the cell with the Indole compound.