发明名称 |
LIQUID PHARMACEUTICAL FORMULATIONS FOR ORAL ADMINISTRATION OF A CGRP ANTAGONIST |
摘要 |
Liquid formulations comprising the compound 1-[1-({[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-trifluoroethyl)azepan-3-yl]amino}carbonyl)piperidin-4-yl]-2-oxo-1,2-dihydroimidazo[4,5-b]pyridin-3-ide have surprisingly improved bioavailability and stability in comprising polyethylene glycol, Tween (polysorbate 80), Cremophor® EL (polyoxyl 35 castor oil), propylene glycol, and optionally water, and may be filled into soft or hard gelatin capsules useful for treating conditions including migraine headache and cluster headache.
|
申请公布号 |
WO2008030524(A3) |
申请公布日期 |
2008.10.02 |
申请号 |
WO2007US19461 |
申请日期 |
2007.09.06 |
申请人 |
MERCK & CO., INC.;BRESLIN, DAVID;STELLABOTT, JOYCE;JAHANSOUZ, HOSSAIN;ALANI, LAMAN, L.;THOMPSON, KAREN |
发明人 |
BRESLIN, DAVID;STELLABOTT, JOYCE;JAHANSOUZ, HOSSAIN;ALANI, LAMAN, L.;THOMPSON, KAREN |
分类号 |
A01N43/00;A61K9/48;A61K9/66;A61K31/55 |
主分类号 |
A01N43/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|