INHIBITORS OF ION CHANNELS

摘要

Compounds, compositions and methods are provided which are useful in the treatment of diseases through the inhibition of sodium ion flux through volt age-gated sodium channels. More particularly, the invention provides substit uted aryl sulfonamides, compositions comprising these compounds, as well as methods of using these compounds or compositions in the treatment of central or peripheral nervous system disorders, particularly pain and chronic pain by blocking sodium channels associated with the onset or recurrence of the i ndicated conditions. The compounds, compositions and methods of the present invention are of particular use for treating neuropathic or inflammatory pai n by the inhibition of ion flux through a voltage-gated sodium channel.