发明名称 |
Antibodies to complementary peptides of thrombin or portions thereof |
摘要 |
Disclosed are antibodies and antigen-binding fragments that bind to a complementary peptide having an amino acid sequence that is encoded by the complement of a nucleotide sequence encoding thrombin or a portion thereof. Such antibodies and antigen-binding fragments can be agonists or antagonists of thrombin receptor-mediated events. Also disclosed are methods of using the agonist antibodies and antigen-binding fragments of the invention to activate the non-proteolytically activated thrombin receptor (NPAR) in a subject in need of such treatment. In addition, methods of using the antagonist antibodies and antigen-binding fragments of the invention to inhibit activation of the NPAR in a subject in need of such treatment are disclosed.
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申请公布号 |
US2008241149(A1) |
申请公布日期 |
2008.10.02 |
申请号 |
US20060521596 |
申请日期 |
2006.09.14 |
申请人 |
CARNEY DARRELL H;BERGMANN JOHN S;FULLER GERALD M |
发明人 |
CARNEY DARRELL H.;BERGMANN JOHN S.;FULLER GERALD M. |
分类号 |
A61K39/395;C07K16/00;C12N5/00;G01N33/53 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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