| 摘要 |
The invention is directed to methods for determining whether a compound inhibits activity of a Parkinson's Disease-associated mutant of leucine-rich repeat kinase-2 (LRRK2). The methods include assessing accumulation of axonal spheroid inclusions, branching and length of neuronal processes, and neuronal cell death. The methods of the invention can be carried out on primary neurons in vitro in a cell culture, or in vivo in an animal. The invention provides methods for the use of NMDA receptor antagonists and anti-oxidants to decrease Parkinson's disease-associated LRRK2 toxicity.
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