摘要 |
The invention provides a radiolabeled affibody molecule comprising a fragment of an IgG-binding domain of protein A from Staphylococcus aureus, a bifunctional linker, and a radiolabel comprising <SUP>18</SUP>F or <SUP>76</SUP>Br, wherein the bifunctional linker links the fragment and the radiolabel. The affibody molecule binds with high affinity to select receptors, which are over-expressed in certain cancers. Since the radionuclides emit a positron, the in vitro and in vivo binding characteristics of the radiolabeled affibody can be assessed using diagnostic imaging. |
申请人 |
GOVERNMENT OF THE UNITED STATES OF AMERICA, REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES;CAPALA, JACEK;KIESEWETTER, DALE, O.;KRAMER-MAREK, GABRIELA;LEE, SANG BONG |
发明人 |
CAPALA, JACEK;KIESEWETTER, DALE, O.;KRAMER-MAREK, GABRIELA;LEE, SANG BONG |