ARTIFICIAL INVAPLEX

摘要

An artificial invasin complex is prepared from purified or recombinantly prepared invasins and gram negative bacteria lipopolysaccharides. Typically, IpaB is mixed with IpaC to form a IpaB:IpaC complex. This invasin protein c omplex is then mixed with the lipopolysaccharide to form an artificial invas in complex. Additional bioactive molecules can be incorporated into the comp lex during manufacture. This artificial invasin complex is similar in functi on to native Invaplex 24 or Invaplex 50. The artificial invasin complex has superior immunogenicity properties relative to the native complex and can be taylor made. Its method of preparation lends itself to scale up. The artifi cial invasin complex can facilitate transport of biomolecules, therapeutics and antibiotics across cell membranes in a manner similar to native Shigella Invaplex.