发明名称 |
ZINC-FINGER NUCLEASE AND RNA INTERFERENCE MEDIATED INACTIVATION OF VIRAL GENOMES |
摘要 |
Embodiments of the present invention provide methods for targeted inactivation of viral genomes. In one embodiment, zinc-finger proteins in which DNA binding sites are altered such that they recognize and bind different, desired DNA sequences contained in hepatitis B virus (HBV) and that include nuclease domains are used for inactivation. Other embodiments for targeted inactivation of viral genomes use small nucleic acid molecules, such as short micro-RNA molecules or short hairpin RNA molecules capable of mediating RNA interference (RNAi) against the hepatitis B virus. |
申请公布号 |
WO2008119000(A1) |
申请公布日期 |
2008.10.02 |
申请号 |
WO2008US58355 |
申请日期 |
2008.03.27 |
申请人 |
UNIVERSITY OF IOWA RESEARCH FOUNDATION;MCCAFFREY, ANTON P.;CRADICK, THOMAS J. |
发明人 |
MCCAFFREY, ANTON P.;CRADICK, THOMAS J. |
分类号 |
C12N15/86;A61K48/00;C12N15/00 |
主分类号 |
C12N15/86 |
代理机构 |
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地址 |
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