A NOVEL METHOD OF PREPARATION OF IMATINIB

摘要

Imatinib base (I) is prepared by a novel method by reduction of N-(2-Methyl-5-nitrophenyl)-4-(3-pyridyl)-2-pyrimidine amine (IV) employing sodium disulphide and condensing the resulting amine N-(5-Amino-2-methylphenyl)-4-(3-pyridyl)-2-pyrimidinamine (II) with the acid chloride 4-[(4-Methylpiperazin-1-yl) methyl]benzoylchloride dihydrochloride (III), in presence of potassium carbonate.