发明名称 |
SUSTAINED RELEASE PREPARATION AND METHOD FOR PRODUCTION THEREOF |
摘要 |
Disclosed is a sustained release preparation which comprises an active ingredient having a higher release rate at pH 4 compared to that in pH 1.2 or pH6.8 and exerts a controlled release of the active ingredient in a pH-independent manner. The sustained release preparation comprises ethyl (-)-2-[4-[2-[[(1S,2R)-2-hydroxy-2-(4-hydroxyphenyl)-1-methylethyl]amino]ethyl]-2,5-dimethyl-phenoxy]acetate hydrochloride as the active ingredient and a pH-independent gel-forming polymer and contains substantially no pH-controlling agent other than the polymer. The sustained release preparation can release the active ingredient in a pH-independent manner in the range from 1.2 to 6.8 and shows a constant release rate for a prolonged period of time. Therefore, the preparation is useful as a therapeutic agent for frequent urination/incontinence of urine which has a long-lasting effect.
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申请公布号 |
EP1974725(A1) |
申请公布日期 |
2008.10.01 |
申请号 |
EP20060843208 |
申请日期 |
2006.12.26 |
申请人 |
KISSEI PHARMACEUTICAL CO., LTD. |
发明人 |
TAKEDA, YASUHIRO;WATANABE, MASAYUKI;NISHIDA, AYUMU |
分类号 |
A61K9/22;A61K31/222;A61K47/32;A61K47/38;A61P13/02 |
主分类号 |
A61K9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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