Substituted pyrrolidinamides, their production and utilisation as medicine

摘要

Substituted amide compounds (I) and their tautomers, enantiomers, diastereomers or salts, are new. Substituted amide compounds of formula (I) and their tautomers, enantiomers, diastereomers or salts, are new. D : a substituted bicyclic ring system; L-E-G-J : a C-C-C-C-group, which is optionally substituted by R 4> and R 5>; L 1>, L 2>C(O); R 4>e.g. H, 1-6C-alkyl, 2-6C-alkenyl or 2-6C-alkynyl; R 5>e.g. H, 1-5C-alkyl or 2-5C-alkenyl; and M : e.g. phenyl or pyridyl ring. With provisos. Full Definitions are given in the DEFINITIONS (Full Definitions) Field. [Image] ACTIVITY : Anticoagulant; Antiinflammatory; Vasotropic; Thrombolytic; Antibacterial; Immunosuppressive; Respiratory-Gen; Antiulcer; Gastrointestinal-Gen; Cardiant; Cerebroprotective; Neuroprotective; Nootropic; Antiparkinsonian; Cytostatic; Antiarthritic; Antirheumatic; Vulnerary. MECHANISM OF ACTION : Thrombosis factor Xa inhibitor; Serine protease inhibitor.