发明名称 |
BIOMATERIAL FOR OSTEOGENESIS CONTAINING OSTEOGENESIS PROMOTER AND NANOGEL |
摘要 |
An object of the present invention is to provide an osteogenic biomaterial which achieves long-term sustained release and localized functional expression of a substance which promotes the formation of bone tissue. The present inventors have found out that a nanogel efficiently encloses an osteogenesis promoting substance to suppress the substance from diffusion into blood, and that the nanogel functions as a carrier for local administration of the osteogenesis promoting substance. Furthermore, they have found out that the osteogenesis promoting substance-containing nanogel can be cross-linked with a water-soluble polymer to allow sustained release of the osteogenesis promoting substance at a local area over a long period of time. Based on these findings, the present invention was completed. The osteogenic biomaterial of the present invention which contains the osteogenesis promoting substance and the nanogel shows osteogenesis promoting activity over a long period of time, and can be used as a preventive and therapeutic agent against bone diseases. |
申请公布号 |
EP1974754(A1) |
申请公布日期 |
2008.10.01 |
申请号 |
EP20070706882 |
申请日期 |
2007.01.17 |
申请人 |
NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL ANDDENTAL UNIVERSITY |
发明人 |
AKIYOSHI, KAZUNARI;NODA, MASAKI |
分类号 |
A61L27/22;A61L27/52 |
主分类号 |
A61L27/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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