3,5-DIHYDROXYBENZOIC ACID DERIVATIVE HAVING ANTI-OBESITY ACTIVITY AND THE PREPARATION METHOD THEREOF

摘要

A 3,5-dihydroxybenzoic acid derivative compound having anti-obesity activity is provided to obtain a pharmaceutical agent for preventing and treating diseases caused by abnormal fat metabolism, including obesity, hyperlipidemia, diabetes by inducing activation of IDH3-alpha and CPT1 promoters. A 3,5-dihydroxybenzoic acid derivative compound having anti-obesity activity is represented by the following formula 1, wherein R is adamantyl, cyclohexyl or hexyl. The 3,5-dihydroxybenzoic acid derivative compound includes N-adamantyl-3,5-dihydroxybenzamide, N-cyclohexyl-3,5-dihydroxybenzamide or N-hexyl-3,5-dihydroxybenzamide.