摘要 |
<p>The device for the determination of the shearing stress load of molecular particles e.g. protein, comprises a mechanical reception (F), two complementary cylindrical all-glass body (C), connections (H) connected by a defined cannula (D) with Luer-lock, two piston rods (B), a locking holder (G), a locking stopper (A), a drive (I), a digital control unit (J), and an integrated optical measuring system. The glass body and the cannula are connected with the mechanical reception. The glass body is filled with a volume of 2-20 ml. The glass bodies are made of syringes. The device for the determination of the shearing stress load of molecular particles e.g. protein, comprises a mechanical reception (F), two complementary cylindrical all-glass body (C), connections (H) connected by a defined cannula (D) with Luer-lock, two piston rods (B), a locking holder (G), a locking stopper (A), a drive (I), a digital control unit (J), and an integrated optical measuring system. The glass body and the cannula are connected with the mechanical reception. The glass body is filled with a volume of 2-20 ml. The glass bodies are made of syringes. The drive is an electromechanical stepping motor for bobbing movement of the glass body. Software is installed for control the parameter speed of shift and number of the repetitions. The inner diameter of the cannula is 2 mm, 1 mm or 0.6 mm. An independent claim is included for a method for the determination of the shearing stress load of a particle dispersed in solution during the filling of the solution.</p> |
申请人 |
BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG |
发明人 |
HEINZELMANN, UDO;GARIDEL, PATRICK DR.;KERN, HANS-JOACHIM DR.;LANGER, ANDREAS;WEBER, JUERGEN |