SUBSTITUTED ANILIDES

摘要

The invention is directed to physiologically active compounds of formula (I) wherein: R1 is hydrogen, halogen, hydroxy, lower alkyl or lower alkoxy; X1, X2 and X6 independently represent N or CR10; and one of X3, X4 and X5 represents CR11 and the others independently represents N or CR10 (where R10 is hydrogen, amino, halogen, hydroxy, lower alkyl, lower alkoxy, lower alkylthio, lower alkylsulphinyl, lower alkylsulphonyl, nitro or trifluoromethyl; and R11 represents a group - L1- Ar1-L2-Y); and the corresponding N-oxides, and their prodrugs; and pharmaceutically acceptable salts and solvates of such compoun ds and their N-oxides and prodrugs. Such compounds have valuable pharmaceutical properties, in particular the ability to regulate th e interaction of VCAM-1 and fibronectin with the integrin VLA-4 (.alpha.4.beta.1).