SULFONAMIDOMETHYL PHOSPHONATE INHIBITORS OF .BETA.-LACTAMASE

摘要

The intention relates to bacterial antibiotic resistance and, in particular, to compositions and methods for overcoming bacterial antibiotic resistance. The invention provides novel .beta.-lactama se inhibitors, which are structurally unrelated to the natural product and semi-synthetic .beta.-lactamase inhibitors presently available, and which do not require a .beta.-lactam pharmacophore. The invention also provides pharmaceutical compositions and methods for inhibiti ng bacterial growth.