| 摘要 |
FIELD: chemistry. ^ SUBSTANCE: invention refers to production method of alpha-racemate of 1-(2-piridyl)-1,2-ethandiol: catalytic reducing (1RS)-1-(2-piridyl)-1,2-ethandiol distinctive in that nickel aluminium alloy is used as catalyst, while reduced at atmospheric active hydrogen pressure generated by reaction (1RS)-1-(2-piridyl)-1,2-ethandiol with sodium hydroxide in aqueous medium, resulted in and beta-racemates of 1-(2-piperidyl)-1,2-ethandiol and their subsequent diethyl ether fractional crystallisation to produce end product applied as raw product for medical product synthesis, such as Ethoxadrol, Dexoxadrol, Levoxadrol, Dioxadrol. ^ EFFECT: higher yield and purity of declared connection, as well as reduction of synthesis stages number. ^ 1 cl, 1 ex |
