Novel pyrroles having hypolipidemic hypocholesteremic activities, process for their preparation and pharmaceutical compositions containing them and their use in medicine

摘要

The present disclosure relates to the use of hypolipidaemic and hypocholesterolemic compounds of formula (I). More specifically, the present disclosure relates to beta-aryl-alpha-substituted propanoic acids of the general formula (I). The compounds of general formula (I) lower or modulate triglyceride levels and/or cholesterol levels and/or lipoproteins (LDL) and raise HDL plasma levels and hence are useful in combating different medical conditions such as type 2 diabetes, impared glucose tolerance, dyslipidaemia, hypertension, obesity, atherosclerosis, hyperlipidaemia, coronary artery disease, cardiovascular disorders, renal diseases, microalbuminuria, glomerulonephritis, glomerulosclerosis, nephritic syndrome, hypertensive nephrosclerosis, diabetic retinopathy, diabetic nephropathy, endothelial cell dysfunction, psoriasis, polycystic ovarian syndrome (PCOS), dementia, end-stage renal disease, osteoporosis, inflammatory bowel diseases, myotonic dystrophy, pancreatitis, arteriosclerosis, xanthoma or cancer.