| 摘要 |
A microemulsion-based hydrogel comprising itraconazole is provided to reduce side effects of itraconazole including liver toxicity and stomach disorder caused by oral administration by application into the local skin, and increase antifungal activity of itraconazole. A microemulsion-based hydrogel comprises itraconazole dissolved in benzyl alcohol as an oil phase, and further comprises surfactant selected from diethyleneglycolmonoether, ethanol and phospholipid and gelating agent selected from carbopol and xanthan gum. A preparation method of the microemulsion-based hydrogel comprises the steps of: solubilizing itraconazole in benzyl alcohol; adding surfactant into the solution to prepare an oil phase; and adding an aqueous phase containing carbopol and xanthan gum into the oil phase.
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