Deuterated catecholamine derivatives and medicaments comprising said compounds

摘要

The disclosure concerns deuterated catecholamine derivatives, such as L-dopa (levodopa), as well as their carboxylic acid esters, utilised, amongst other things, in the treatment of Parkinson's disease and restless leg syndrome, as well as pharmaceuticals containing these compounds. More specifically the disclosure concerns deuterated catecholamine derivatives of the general formula (I) wherein: R1 is H or D, R2 indicates H or D, R3 is H, D, C1-C6 alkyl or C5 to C6-cycloalkyl, deuterated C1 to C6-alkyl or C5 to C6-cycloalkyl, R4 indicates H or D and R5 is H or D, with the exception of L-2-amino-3,3-dideutero-3-(3,4-dihydroxyphenyl) propionic acid.