| 摘要 |
The present invention provides a method of making solid micropellets of which at least 75% by weight have a diameter less than 500 µm comprising
(i) melting one or more binders; and
(ii) combining the one or more binders melted in step (i) with a pharmaceutically active ingredient to form solid micropellets. Solid micropellets obtainable by this method are also provided. The invention has particular utility for improving the solubility of poorly water-soluble pharmaceutically active ingredients.
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