发明名称 CRYSTALS OF 5-[{6-(2-FLUOROBENZYL)OXY-2-NAPHTHYL}METHYL]-2,4-THIAZOLIDINEDIONE
摘要 The invention relates to type A crystal of 5-[{6-(2-fluorobenzyl)oxy-2- naphthyl}methyl]-2,4-thiazolidinedione characterized to have characteristic absorption peaks (2.theta.) at 11.5.degree.~0.3.degree., 14.5.degree.~0.2.degree., 16.2.degree.~0.3.degree., 17.0.degree.~0.3.degree., 17.7.degree.~0.2.degree., 18.6.degree.~0.3.degree., 19.1.degree.~0.2.degree., 21.3.degree.~0.4.degree., 22.4.degree.~0.5.degree., 25.7.degree.~0.5.degree. and 28.3.degree.~0.5.degree. in a powder X-ray diffraction pattern, and also to a method for preparation thereof, and a pharmaceutical composition comprising the same. The crystal is excellent in stability, and has advantages in handling, storage, and pharmaceutical preparation. The invention also relates to type B, C and D crystals of said compound.
申请公布号 CA2351727(C) 申请公布日期 2008.09.23
申请号 CA19992351727 申请日期 1999.11.19
申请人 MITSUBISHI CHEMICAL CORPORATION 发明人 UENO, HIROAKI;MASUDA, KATSUHIKO;MARUYAMA, AKIRA;OE, TAKAYUKI
分类号 C07D277/20;C07D277/34;A61K31/426;A61P1/18;A61P3/06;A61P3/10;A61P19/06;A61P35/02 主分类号 C07D277/20
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