摘要 |
A compound of formula (I) and pharmaceutically acceptable salts, solvates and hydrolysable esters thereof Wherein X<SUB>1 </SUB>represents O or S; R<SUP>1 </SUP>and R<SUP>2 </SUP>are independently H or C<SUB>1-3 </SUB>alkyl or R<SUP>1 </SUP>and R<SUP>2 </SUP>which are bonded to the same carbon atom may together with the carbon atom to which they are bonded form a 3-5 membered cycloalkyl ring; R<SUP>3 </SUP>and R<SUP>4 </SUP>independently represent H, halogen, -CH<SUB>3 </SUB>and -OCH<SUB>3</SUB>; R<SUP>5 </SUP>represents H or C<SUB>1-6 </SUB>alkyl X<SUB>2 </SUB>represents NH, NCH<SUB>3 </SUB>or O; One of Y and Z is N, and the other is O or S; R<SUP>6 </SUP>represents phenyl or pyridyl (wherein the N is in position 2 or 3) and is optionally substituted by one or more halogen, CF<SUB>3</SUB>, C<SUB>1-6 </SUB>straight or branched alkyl (optionally substituted by halogen), with the provision that when R<SUP>6 </SUP>is pyridyl, the N is unsubstituted. |