发明名称 |
Neurothrophic components of the ADNF I complex |
摘要 |
This invention relates to Activity Dependent Neurotrophic Factor I complex (ADNF I complex) and polypeptides of this complex, which produce their neurotrophic effects through multiple proteases intrinsic to the ADNF I complex. The invention also relates to pharmaceutical compositions comprising ADNF I complex polypeptides, as well as methods for reducing neuronal cell death in vitro and in vivo, methods for treating oxidative stress in a patient, methods for reducing a condition associated with fetal alcohol syndrome in a subject, and methods of enhancing learning and memory both pre- and post-natally, all of which methods use the ADNF I complex polypeptides of the invention.
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申请公布号 |
US7427590(B2) |
申请公布日期 |
2008.09.23 |
申请号 |
US20040489515 |
申请日期 |
2004.10.14 |
申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES;RAMOT AT TEL-AVIV UNIVERSITY, LTD. |
发明人 |
BRENNEMAN DOUGLAS E.;CASTELLON RAQUEL;SPONG CATHERINE Y.;HAUSER JANET M.;GOZES ILLANA |
分类号 |
A61K38/03;A61K38/00;A61K38/04;A61K38/08;A61K38/10;C07K4/12;C07K7/06;C07K7/08;C07K14/475;C07K14/48 |
主分类号 |
A61K38/03 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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