THROMBOSPONDIN-DOMAIN-DEFICIENT R-SPONDIN 1 PROTEIN AS GASTROINTESTINAL TRACT EPITHELIAL PROLIFERATION FACTOR

摘要

The present invention relates to an agent for promoting epithelial proliferation and a method for promoting epithelial proliferation, particularly to an agent for promoting gastrointestinal tract-epithelial proliferation and a method for promoting gastrointestinal tract-epithelial proliferation. The present invention further relates to an agent for treatment or prevention of gastrointestinal tract-epithelium-associated diseases or disorders, and to a method for treating or preventing gastrointestinal tract-epithelium- associated diseases or disorders. The present invention further relates to the use of an R-spondin 1 variant protein, which lacks the thrombospondin type 1 repeat, or the nucleic acid encoding the same.